Creatinine is a waste product from the digestion of protein in our food and the normal breakdown of muscle tissue. It is removed from the blood through your kidneys.

The serum creatinine is a blood test parameter used to check how well kidneys are filtering blood. The serum (blood) creatinine test is often used in monitoring for

➟ Chronic kidney disease (CKD)
➟ People with symptoms of acute kidney injury (AKI)
➟ In contrast studies
➟ In estimation of dose adjustments for medications
➟ Calculate the estimated glomerular filtration rate (eGFR)

Creatinine clearance is important because it measures how well the kidneys are functioning of filtering blood, which helps in screening, diagnosing, and monitoring kidney disease for short as well as long term.

The Cockcroft and Gault formula (CG) was developed in 1973. The original formula was developed using data from 249 men and is not adjusted for body surface area, which can make it less accurate in obese or underweight patients. The Cockcroft-Gault formula is still widely used, particularly for drug dosing adjustments of medications that are largely renally excreted and have a narrow therapeutic index.

Our creatinine clearance calculator simplifies the Cockcroft–Gault–Formula based calculation, reducing manual errors and saving time in busy clinical settings.

Creatinine clearance is especially important when prescribing renally cleared drugs, adjusting doses in elderly or critically ill patients, and monitoring progression of chronic kidney disease. It also serves as a useful educational tool for understanding kidney physiology, filtration, and the relationship between serum creatinine, muscle mass, and GFR.

Lower creatinine clearance values generally indicate impaired kidney function and may suggest underlying chronic kidney disease or acute changes in renal perfusion.